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3 of the patients experienced no detectable serum concentrations of metronidazole at any time point. The necessarily mean dose of gel utilized for the duration of clinical studies was 600 mg which signifies 4.5 mg of metronidazole for each application. Therefore, below standard usage degrees, the formulation affords negligible serum concentrations of metronidazole. The mechanisms by which METROGEL® (metron-idazole topical gel) Topical Gel acts during the treatment method of rosacea are not known, but show up to incorporate an anti-inflammatory impact.
Utilize and rub in a skinny movie of METROGEL® Topical Gel two times each day, early morning and evening, to total influenced parts following washing.
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The pharmacodynamics of metronidazole in Affiliation with the therapy of rosacea are not known. Cardiac Electrophysiology: The outcome of METROGEL on the QTc interval hasn't been sufficiently characterized.
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